Registration Dossier
Registration Dossier
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EC number: 248-096-5 | CAS number: 26896-48-0
Endpoint summary
Administrative data
Description of key information
Additional information
Stability
Hydrolysis
In water, octahydro-4,7-methano-1H-indenedimethanol (TCD-Alcohol DM) is expected to be hydrolytically stable due to the absence of hydrolysable groups (GUBDH, 2008).
Biodegradation
Biodegradation in water: screening test
In the key study (LAUS, 2015), Octahydro-4,7-methano-1H-indenedimethanol (TDC-Alcohol DM) was assessed for ready biodegradability in the CO2 -evolution test according to OECD 301B (performed compliant with GLP). No degradation was observed within 28 days (0% within both replicates) while the test item was not toxic to the inoculum at a concentration of 29.0 mg/L.
This is supported by a MITI (I) test according to OECD TG 301 C (NITE, 2004), where TDC-Alcohol DM has been demonstrated to be not readily biodegradable.
Biodegradation in water and sediment: simulation test
Octahydro-4,7-methano-1H-indenedimethanol (TCD Alcohol DM) was determined to be rapidly transformed to the dicarboxylic acid derivative in a reliable and valid simulation test on degradation in surface water (OECD TG 309; Noack, 2021). Any losses due to adsorption could reliably be excluded based on a mass balance of ca. 100 %. No relevant further information could be expected from additional simulation testing with sediment.
Biodegradation in soil
Waiving argument:
A study on soil simulation testing is scientifically not necessary: TCD Alcohol DM does not have a high potential for adsorption (log Kow < 3 IUCLID Sect. 4.7, low estimated Koc of 16.8, IUCLID Sect. 5.4.1). Based on the valid simulation test on degradation in surface water (OECD TG 309; Noack, 2021), TCD Alcohol DM is rapidly transformed to the dicarboxylic acid derivative. Any losses due to adsorption could reliably be excluded based on a mass balance of ca. 100 %. No relevant further information could be expected from additional simulation testing with soil.
Mode of degradation in actual use
Data for mode of degradation in actual use are not required under REACH.
Bioaccumulation
Aquatic/sediment
Because of an experimentally determined low log Kow value between 1.2 and 2.1 (NITE, 2004), supported by a calculated log Kow of 1.91 (KOWWIN Program v1.67), no relevant bioconcentration and bioaccumulation potential is expected. Based on the calculated value for log Kow, the log BCF of octahydro-4,7 -methano-1H-indenedimethanol (TCD-Alcohol DM) was estimated to be 0.768 (BCF = 5.866) (GUBDH, 2008). The potential for bioaccumulation in aquatic and benthic organisms is therefore expected to be low.
Transport and Distribution
Adsorption/Desorption
Based on a calculated log Koc of 1.2255 (Koc = 16.81), octahydro-4,7-methano-1H-indenedimethanol (TCD-Alcohol DM) is expected to exhibit low adsorption to particulate matter, sediment and soil (GUBDH, 2008).
Henry’s Law constant
The Henry's law constant (HLC) of octahydro-4,7-methano-1H-indenedimethanol (TCD-Alcohol DM) was determined by calculation (program HENRYWIN v 3.1, US EPA EPI Suite) (GUBDH, 2008).
Bond estimation method: HLC (25°C) = 1.91E-007 atm*m3/mol
Goup estimation method: HLC (25°C) = 8.10E-012 atm*m3/mol
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