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EC number: 464-300-7
CAS number: -
Administration of the test item by oral route (gavage) to Wistar rats
for 4 weeks did not elicit any effects on body weights, body weight
changes or food consumption when given at 150, 450 or 1000 mg/kg/day.
The only relevant clinical sign observed was soiled urogenital region in
some principal and satellite females given 1000 mg/kg/day or 450
mg/kg/day. The estrous cycle stage was not affected at any dose-level
and there were no treatment-related changes in neurotoxicological
parameters. Hematological, blood biochemical parameters or organ weights
were not affected by the treatment. No relevant necropsy and
histopathology findings were noted in any treated group. Consequently,
under the experimental conditions of this study, the No Observed Adverse
Effect Level (NOAEL) was 1000 mg/kg/day.
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