1,1'-(p-tolylimino)dipropan-2-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

16.02.2001 - 10.04.2001

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: OECD guideline and GLP study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2001

Report date:

2001

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Version / remarks:

adopted 1996

Deviations:

no

GLP compliance:

yes

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

1,1'-(p-tolylimino)dipropan-2-ol

EC Number:

254-075-1

EC Name:

1,1'-(p-tolylimino)dipropan-2-ol

Cas Number:

38668-48-3

Molecular formula:

C13H21NO2

IUPAC Name:

1,1'-(p-tolylimino)dipropan-2-ol

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Harlan Italy S.r.l., 33049 San Pietro al Natisone
- Age at study initiation: 5 to 6 weeks
- Weight at study initiation: 120 to 150 grams
- Fasting period before study: overnight fast prior to dosing
- Housing: polycarbonate cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24°C
- Humidity (%): 40-70 %
- Photoperiod (hrs dark / hrs light): 12 hours light and 12 hours dark

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

DOSE VOLUME APPLIED: 10 mL/kg bw

Doses:

25, 200, 2000 mg/kg bw

No. of animals per sex per dose:

3 males (2000 and 200 mg/kg bw)
3 males and females (25 mg/kg bw)

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Body weight: at allocation to the study (day -1), prior the dosing (day 1) and on day 8 and 15
- Clinical signs: 1,2 and 4 hours after dosing and daily thereafter for a total of 14 days

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 25 - < 200 mg/kg bw

Based on:

test mat.

Mortality:

25 mg/kg bw: no death
200 mg/kg bw: 2/3 males within 1 hour after dosing
2000 mg/kg bw: 3/3 males within 1 hour after dosing

Clinical signs:

other: 25 mg/kg bw : no clinical signs were observed 200 mg/kg bw: 2/3 males showed convulsions and pronation approximately 5 minutes after dosing 2000 mg/kg bw: 3/3 males showed convulsions appproximately 1 minute after dosing

Gross pathology:

Abnormal content (yellow or pale mucoid or creamy material) in the stomach and in the jejunum of the early decedent male animals.
Skin/fur staining around the perioral/perinasal region in early decedent male animals.