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EC number: 425-220-8
CAS number: 5945-33-5
Maximum concentration not causing irritating effects in preliminary
Signs of irritation during induction: Very slight (3 animals) to
moderate to severe erythema (7 animals) was noted after the intradermal
induction at the 24 hour reading, and very slight to severe erythema
after 48 hours.
After topical induction, very slight erythema was oberved in all test
animals and very slight oedema was noted in 4 test group animals at 1
-hour reading. No dermal reactions were noted after 24hours.
One test group animal was killed due to weight loss and breathing
difficulties on day 16. These effects were not considered to be
No adverse effects on bodyweight gain were noted.
The test chemical was non-sensitising to the skin of guinea pigs
According to OECD TG 406, Maximisation test of Magnusson and Kligman was
accomplished and concluded that test material did not induce skin
sensitisation in guinea pigs.
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