Registration Dossier
Registration Dossier
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EC number: 425-220-8 | CAS number: 5945-33-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with GLP
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 000
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 997
- Reference Type:
- other: monograph provided by ECHA
- Title:
- Endpoint record:Eye irritation
- Author:
- ECHA
- Year:
- 2 010
- Bibliographic source:
- Document from ECHA
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- There is no need to add in this field.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 5945-33-5
- EC Number:
- 611-829-8
- Cas Number:
- 5945-33-5
- IUPAC Name:
- 5945-33-5
- Reference substance name:
- -
- EC Number:
- 425-220-8
- EC Name:
- -
- Cas Number:
- 5945-33-5
- Molecular formula:
- C39H34O8P2
- IUPAC Name:
- 4-(2-{4-[(diphenoxyphosphoryl)oxy]phenyl}propan-2-yl)phenyl diphenyl phosphate; 4-{2-[4-({[4-(2-{4-[(diphenoxyphosphoryl)oxy]phenyl}propan-2-yl)phenoxy](phenoxy)phosphoryl}oxy)phenyl]propan-2-yl}phenyl diphenyl phosphate
- Details on test material:
- Nature of substance:Undiluted liquid
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Nothing to add in this field.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- 72hours
- Observation period (in vivo):
- 3 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- Nothing to add in this field.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 1
- Irritation parameter:
- conjunctivae score
- Max. score:
- 1
- Remarks on result:
- other: Max. duration: 1h; Max. value at end of observation period :0(related to all animals)
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Irritation parameter:
- chemosis score
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: 0h; Max. value at end of observation period :0(related to all animals)
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 24, 28 and 72 hours
- Score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Irritation parameter:
- cornea opacity score
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: 0 h; Max. value at end of observation period :0(related to all animals)
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Irritation parameter:
- iris score
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: 0 h; Max. value at end of observation period :0(related to all animals)
- Irritant / corrosive response data:
- No corneal or iridial effects were noted during the study.
- Other effects:
- Residual test material was noted around the treated eye of one animal one hour after treatment.
Minimal conjunctival redness was noted in one treated eye one hour after treatment.
Any other information on results incl. tables
All treated eyes appeared normal at the 24-hour observation. Mean scores for all ocular lesions at 24, 48 and 72 hours were 0 for all animals.The test chemical was non-irritating to the eyes of rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test chemical was non-irritating to the eyes of rabbits.
- Executive summary:
According to OECD TG 405, the test material was considered not irritating to eye via acute eye irriation/corrosion study in rabbits.
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