Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 425-220-8 | CAS number: 5945-33-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Mar. 1, 2011 to May.25, 2011.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- OECD guideline test with GLP compliance, but without GLP certificate. Furthermore prior to initiating the definitive test, a preliminary test was performed at concentrations of 0.125, 0.25, 0.5 and 1.0 mg/L without GLP compliance. Therefore this study should be used with restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Deviations:
- yes
- Remarks:
- The temperature of artificial climate chamber was measured but not the test medium. This deviation does not affect the validity of the study.
- GLP compliance:
- yes
- Remarks:
- This stud y has been inspected in accordance with the GLP Principles as published by OECD [ENV/MC/CHEM (98)17] in 1998.
Test material
- Reference substance name:
- 5945-33-5
- EC Number:
- 611-829-8
- Cas Number:
- 5945-33-5
- IUPAC Name:
- 5945-33-5
- Reference substance name:
- -
- EC Number:
- 425-220-8
- EC Name:
- -
- Cas Number:
- 5945-33-5
- Molecular formula:
- C39H34O8P2
- IUPAC Name:
- (1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate
- Reference substance name:
- (1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate
- IUPAC Name:
- (1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate
- Test material form:
- other: liquid
- Details on test material:
- Same with the substance notified in the section 1 of this dossier
Constituent 1
Constituent 2
Constituent 3
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- At 0 hours and 14 days after exposure, 2 ×approximately 100 mL samples from each test solution were taken from additional beakers (in parallel to the other test solutions). In other words, 2 ×approximately 100 mL samples from each test solution was taken from the freshly prepared test solutions. At 48 hours and 16 days after exposure, 3 ×approximate 50 mL samples were taken from each concentration and analyzed. In addition, one sample was taken from the solvent control approximate 100 mL.
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- Prior to initiating the definitive test, a preliminary test was performed at concentrations of 0.125, 0.25, 0.5 and 1.0 mg/L (Non-GLP state).
The solubility of BDP in the test solution was not more than 0.5 mg/L, and there was no significant difference between the number of offspring in each test concentration and solvent controls. Based on the results of the pre-test, test concentrations of 0.20 and 0.40 mg/L were selected.
Stock solution: 107.2 mg test substance (with purity of 98.38%) was fully dissolved and made up to 25 mL with dimethylformamide (DMF) to obtain the stock solution of 4218 mg/L. Then the stock solution was diluted to destinated concentrations of 0.20 and 0.40 mg/l.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Obey with the OECD guideline 211.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Post exposure observation period:
- no data
Test conditions
- Hardness:
- in the range of 207-226 mg/L (CaCO3)
- Test temperature:
- 19.1-20.1°C
- pH:
- 7.6-8.5
- Dissolved oxygen:
- 9.6-10.7 mg/L
- Salinity:
- no data
- Nominal and measured concentrations:
- Nominal concentrations: 0.2 and 0.4 mg/l; The measured concentrations of the fresh test solutions and old solution after 48 hours renewal were in the range of 95 %-110 % of nominal concentration 0.2 mg/L; the measured concentration were in the range of 83 %-103 % of nominal concentration of 0.4 mg/L in fresh test solution and old solution after 48 h renewal. Therefore, the toxic effect values were calculated based on the nominal concentration.
- Details on test conditions:
- Obey with the OECD guideline 211.
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Livability at birth
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- Mortality of parent animals
- Details on results:
- Compared with the blank control, there was no significant difference among the solvent control, test concentrations of 0.20 mg/l and 0.40 mg/L on the fecundity, mortality of the parent animals, livability of offspring at the birth. At the concentration of 0.4 mg/L, the length of parental animal was longer than that of blank control, had significant difference.
- Results with reference substance (positive control):
- Not required
- Reported statistics and error estimates:
- Results of the toxicity test were interpreted by standard statistical techniques using the function of data analysis in EXCEL Version 2003. The mean number of dead and living offspring per parent animals was calculated, respectively. The NOEC was estimate by One Way Analysis of Variance (One Way ANOVA).
Any other information on results incl. tables
In the pre-test, The test concentrations were selected for concentration analysis during pretest. For the nominal concentration of 1 mg/L, both the measured concentration at 0 h and 24 h were 42 % of the nominal concentration, which indicated that the test substance was not fully dissolved in the test medium. From the analytical result, the test substance was not fully dissolved in the test medium at the concentration of 1 mg/L. Therefore, the data at the concentration of 1 mg/L was not used for toxicity assessment. Based on the results of the pre-test, test concentrations of 0.20 and 0.40 mg/L were selected for definitive test.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- OECD guideline test
- Conclusions:
- In the Daphnia magna reproduction test, on the basis of the nominal concentrations, the NOEC of BDP to Daphnia magna is ≥0.40 mg/L, and which was above the water solubility of BDP.
- Executive summary:
Reproduction Test (21 days, Semi-Static System) of BDP to Daphnia magna Straus was conducted in accordance with OECD test guideline 211, under semi-static conditions with two test concentrations of 0.20 and 0.40 mg/L.Ten test daphnids were exposed to each test concentration and controls for a period of 21 days. For each concentration and the control, 10 replicates were performed. Each replicate contained only one daphnid. The daphnids were observed for reproduction and growth during the exposure. The measured concentration of test substance was in the range of 83 % to102 % of nominal values in the fresh (0 hour) and old test solution (48 hours). Th erefore, all effect values were given based on the nominal concentration. The calculations and values were based on 0.20 and 0.40 mg/L nominal concentrations. From the test, the results show that on the basis of the nominal concentrations, the NOEC of BDP to Daphnia magna is not less than0.40 mg/L, and which means the NOEC was not less the water solubility determined for BDP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

Route: .live1