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EC number: 290-476-8
CAS number: 90170-43-7
Assume 1:1 as per guidance. Based on rat inhaltion rate 0.38 m3/hour
Assumes 20% dermal absorption based on research on cosmetic ingredients of this type
28 day oral
rat NOAEL: 43 mg/kg bw/day (nominal) (male/female) based on: test mat.
28 day oral
rat LOAEL: 160 mg/kg bw/day (actual dose received) (male/female) based
on: test mat. (Based on decreased body weight gain in males and females
during the pre-mating period, and an increased incidence of microscopic
lesions in the kidneys of males and acanthosis of the glandular and
non-glandular stomach of females.)
effects at 160 mg/kg are considered either adaptive and not relevant for
humans, the figure of 160 mg/kg/day is used to set the human DNEL and as
a basis for classification.
A number of
similar substances are undergoing registration and collective review of
data may be needed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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