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Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
4 March 1999 - 2 April 1999
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was performed according to OECD guidelines and GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1999
Report date:
1999

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Identification: PDTN
Description: White crystalline solid
Chemical name: Acetonitrile, 2,2',2",2"'-(1,3-propanediyldinitrilo)tetrakis(9 CJ)
CAS-No.: 110057-45-9
Batch:JNN98038
Purity: 99.2%
Test substance storage: At room temperature in the dark
Stability under storage conditions: stable
Radiolabelling:
no

Study design

Analytical monitoring:
yes

Results and discussion

Dissipation DT50 of parent compoundopen allclose all
pH:
4
Temp.:
80 °C
Hydrolysis rate constant:
0.195 h-1
DT50:
3.56 h
Type:
(pseudo-)first order (= half-life)
pH:
4
Temp.:
70 °C
Hydrolysis rate constant:
0.043 h-1
DT50:
15.9 h
Type:
(pseudo-)first order (= half-life)
pH:
4
Temp.:
25 °C
Hydrolysis rate constant:
0 h-1
DT50:
46 659 h
Type:
(pseudo-)first order (= half-life)
pH:
7
Temp.:
80 °C
Hydrolysis rate constant:
0.206 h-1
DT50:
3.37 h
Type:
(pseudo-)first order (= half-life)
pH:
7
Temp.:
70 °C
Hydrolysis rate constant:
0.048 h-1
DT50:
14.5 h
Type:
(pseudo-)first order (= half-life)
pH:
7
Temp.:
25 °C
Hydrolysis rate constant:
0 h-1
DT50:
34 361 h
Type:
(pseudo-)first order (= half-life)
pH:
9
Temp.:
70 °C
Hydrolysis rate constant:
0.053 h-1
DT50:
13.1 h
Type:
(pseudo-)first order (= half-life)
pH:
9
Temp.:
55 °C
Hydrolysis rate constant:
0.011 h-1
DT50:
62.7 h
Type:
(pseudo-)first order (= half-life)
pH:
9
Temp.:
25 °C
Hydrolysis rate constant:
0 h-1
DT50:
2 310 h
Type:
(pseudo-)first order (= half-life)

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
At pH 4, half-life times are 3.56 hours and 15.9 hours at 80C and 70C, respectively. From these values the half-life time at pH 4 and 25C was calculated to be 46659 hours (5.3 years).
At pH 7, half-life times are 3.37 hours and 14.5 hours at 80C and 70C, respectively. From these values the half-life time at pH 7 and 25C was calculated to be 34361 hours (3.9 years).
At pH 9, half-life times are 13.1 hours and 62.7 hours at 70C and 55C, respectively. From these values the half-life time at pH 9 and 25C was calculated to be 2310 hours (0.3 years).
Executive summary:

The determination of the hydrolysis as a function of pH was based on the EEC-Directive 92/69 EEC, Part C, Methods for the determination of Ecotoxicity, C.7: "Abiotic degradation: Hydrolysis as a function of pH".