(1R,2S,5S)-2-(methoxycarbonyl)-6,6-dimethyl-3-azoniabicyclo[3.1.0]hexane chloride

GHS

General Information

Name:

PF-04349713-01

Not classified

Type of classification:

self-classification

Remarks:

Worker safety testing is ongoing for this substance, the preliminary result for skin sensitization "Skin Sensitisation Study of PF-04349713-01 in Guinea Pigs (Buehler Test)" - Study No.: G2155E0060 detailed in section 7.  Based on the preliminary result PF-04349713-01 is not a skin sensitizer to Guinea pigs. The results do not meet the GHS classification criteria for skin sensitisation (Buehler Test). While this is not in-line with the majority of CLP notifiers listed on the ECHA website, no data is available to support the notified classifications.  In addition, until further test data is available PF-04349713-01 is internally categorized under the Pfizer OEB (Occupational Exposure Band) as band 3 (10-100ug/m3). The substance was not assigned the lower default band 4 (1-10ug/m3) based on Insilico data. The SDS attached to section 13.2 details the OEB. In addition the SCC (Strictly Controlled Conditions) assessment details risk mitigation measures to reduce both occupational & environmental exposure.  - see attached to section 1.9

Classification

Physical hazards

Explosives

Reason for no classification:

data lacking

Flammable gases and chemically unstable gases

Reason for no classification:

data lacking

Aerosols

Reason for no classification:

data lacking

Reason for no classification:

data lacking

Oxidising gases

Reason for no classification:

data lacking

Gases under pressure

Reason for no classification:

data lacking

Flammable liquids

Reason for no classification:

data lacking

Flammable solids

Reason for no classification:

data lacking

Self-reactive substances and mixtures

Reason for no classification:

data lacking

Pyrophoric liquids

Reason for no classification:

data lacking

Pyrophoric solids

Reason for no classification:

data lacking

Self-heating substances and mixtures

Reason for no classification:

data lacking

Substances and mixtures which in contact with water emit flammable gases

Reason for no classification:

data lacking

Oxidising liquids

Reason for no classification:

data lacking

Oxidising solids

Reason for no classification:

data lacking

Organic peroxides

Reason for no classification:

data lacking

Corrosive to metals

Reason for no classification:

data lacking

Desensitized explosives

Reason for no classification:

data lacking

Health hazards

Acute toxicity - oral

Reason for no classification:

data lacking

Acute toxicity - dermal

Reason for no classification:

data lacking

Acute toxicity - inhalation

Reason for no classification:

data lacking

Skin corrosion / irritation

Reason for no classification:

data lacking

Serious eye damage / eye irritation

Reason for no classification:

data lacking

Respiratory sensitisation

Reason for no classification:

data lacking

Skin sensitisation

Reason for no classification:

data conclusive but not sufficient for classification

Aspiration hazard

Reason for no classification:

data lacking

Reproductive toxicity

Reason for no classification:

data lacking

Effects on or via lactation

Reason for no classification:

data lacking

Germ cell mutagenicity

Reason for no classification:

data lacking

Carcinogenicity

Reason for no classification:

data lacking

1. Specific target organ toxicity - single (STOT-SE)

Reason for no classification:

data lacking

1. Specific target organ toxicity - repeated (STOT-RE)

Reason for no classification:

data lacking

Environmental hazards

Hazardous to the aquatic environment (acute / short-term)

Reason for no classification:

data lacking

Hazardous to the aquatic environment (long-term)

Reason for no classification:

data lacking

Hazardous to the ozone layer

Reason for no classification:

data lacking