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Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

13 Nov 2018 - 05 Mar 2019

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Type of method:

column elution method

Water solubility:

>= 125 - <= 133 µg/L

Temp.:

20 °C

pH:

6.3

Remarks on result:

other: formal mean value 129 µg/L

Results
The concentrations of the test item in the different test solutions were calculated automatically using the equation of the calibration curve. The results for the duplicate analyses are listed in the following table:

Flow rate 25.0 mL/h, pH 6.3 throughout

Fraction no. (combined aliquots)	Concentration of test item (µg) in 0.5 µL Peak 1^a	Concentration of test item (µg) in 0.5 µL Peak 2^b	Water solubility (µg/L)* peak 1^a	Water solubility (µg/L) peak 2^b
1 (11-12)	2.3	2.7	115	135
2 (13-14)	2.4	2.6	120	130
3 (15-16)	2.4	2.7	120	135
4 (17-18)	2.4	2.7	120	135
5 (19-20)	2.8	2.7	140	135
6 (21-22)	2.8	2.7	140	135
7 (23-24)	2.5	2.6	125	130
8 (25-26)	2.7	2.6	135	130

 

Flow rate 12.5 mL/h, pH 6.3 throughout

Fraction no. (combined aliquots)	Concentration of test item (µg) in 0.5 µL Peak 1^a	Concentration of test item (µg) in 0.5 µL Peak 2^b	Water solubility (µg/L)* peak 1^a	Water solubility (µg/L) peak 2^b
1 (11-12)	2.4	2.6	120	130
2 (13-14)	2.6	2.7	130	135
3 (15-16)	2.4	2.6	120	130
4 (17-18)	2.7	2.7	135	135
5 (19-20)	2.4	2.7	120	135
6 (21-22)	2.5	2.6	125	130
7 (23-24)	2.6	2.7	130	135
8 (25-26)	2.2	2.6	110	130

*the concentration is related to 20 mL water fraction

^ahexadecanoic acid methyl ester

^boctadecanoic acid methyl ester

 

The following result for water solubility of the test item can thus be reported:

The water solubility ranges from 125 µg/L – 133 µg/L (formal mean value: 129 µg/L)

 

The water solubility was determined at 20 °C. The pH value of the collected aqueous fractions was 6.3.

 

Please note: the investigated blank value yielded a concentration of the lowest concentration level. Due to this fact, it is likely possible, that the water solubility is < 120 µg/L.

Description of key information

0.129 mg/L at 20 °C and pH 6.3 (column elution method, OECD 105)

Key value for chemical safety assessment

Water solubility:

0.129 mg/L

at the temperature of:

20 °C

Additional information

The water solubility of the test item ranges from 125 µg/L to 133 µg/L (formal mean value 129 µg/L).