3,5-bis(2,4-dimethylcyclohex-3-en-1-yl)polyheterocycle

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics, other

Data waiving:

other justification

Justification for data waiving:

other:

Data source

Reference

Reference Type:

secondary source

Title:

Unnamed

Year:

1992

Materials and methods

Test guideline

Qualifier:

no guideline followed

GLP compliance:

not specified

Test animals

Species:

other: not applicable

Strain:

other: not applicable

Sex:

not specified

Administration / exposure

Route of administration:

dermal

Vehicle:

not specified

Control animals:

not specified

Applicant's summary and conclusion

Conclusions:

Sa 57 might be able to penetrate the skin to a limited extent

Executive summary:

There are no dermal penetration/absorption studies available for Sa 57. Dermal penetration strongly depends on the molecular weight of a substance and its lipophilic properties. Typically a molecular weight above 500 prevents a substance from penetrating the skin. The lipophilic properties of a chemical are indicated by the octanol-water partition coefficient (log Kow). Substances with a molecular weight below 500 and log Kowvalues between +1.0 and +4.0 are assumed to be able to penetrate the skin. Log Kowvalues below +1.0 or above +4.0 indicate decreasing penetration ability while log Kowvalues below -1.0 or above +6.0 suggests that a substance is not likely to penetrate the skin*. Sa 57 has a molecular weight of 331 and a log Pow of 3.38. According to this data it must be considered that Sa 57 might be able to penetrate the skin, though to a limited extent. There is no information available to predict the fate of Sa 57 after dermal penetration. However, taking into account its physico-chemical properties it is likely to become degraded by releasing its starting monomers.

*Basic principles according to: US-EPA “Dermal Exposure Assessment: Principles and Applications”. EPA/600/8-91-011B, January 1992