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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
relative self-ignition temperature (solids)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
02 November 2016 - 18 November 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.16 (Relative Self-Ignition Temperature for Solids)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
(2S,3S)-3-({5-fluoro-2-[5-fluoro-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}amino)bicyclo[2.2.2]octane-2-carboxylic acid
EC Number:
821-185-1
Cas Number:
1777721-63-7
Molecular formula:
C27H25F2N5O4S
IUPAC Name:
(2S,3S)-3-({5-fluoro-2-[5-fluoro-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}amino)bicyclo[2.2.2]octane-2-carboxylic acid
Test material form:
solid: particulate/powder
Details on test material:
- Name of the test material (as cited in study reports): JNJ-63757109-AAA (T003690)
- Physical state: solid (powder)
- Appearance: white to slightly yellow power
Specific details on test material used for the study:
- Batch n°: I16BD1072
- Analytical purity: 100.0%
- Expiration date: 04 March 2018

Results and discussion

Relative self-ignition temperature (solids)
Key result
Remarks on result:
no self ignition observed under the test conditions

Any other information on results incl. tables

No significant endothermic or exothermic effect of the test item was observed between 20°C and 400°C. It demonstrated that the test item is not self-ignitable.

After the experiment, the test item had turned into a charred residue and was partially collected in a container that was placed below the cube. It indicated that the test item had decomposed and/or reacted during the experiment.

 

Applicant's summary and conclusion

Conclusions:
Based on the results of the EC A.16 test performed, the test item is considered ‘not self-ignitable’.
Because there were no indications of self-heating observed in this test, the test item was considered ‘not self-heating’ and the main study according to UN N.4 was not performed.