Registration Dossier
Registration Dossier
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EC number: 626-424-1 | CAS number: 59572-10-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- up-and-down procedure
Test material
- Reference substance name:
- 1,3,6,8-Pyrenetetrasulfonic acid, sodium salt (1:4)
- EC Number:
- 626-424-1
- Cas Number:
- 59572-10-0
- Molecular formula:
- C16H16O12S4.4Na
- IUPAC Name:
- 1,3,6,8-Pyrenetetrasulfonic acid, sodium salt (1:4)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Remarks:
- Sprague-Dawley derived, albino
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- 2000mg/kg
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- All animals survived test substance administration
- Clinical signs:
- other: There were no signs of gross toxicity, adverse clinical effects, or abnormal behavior.
- Gross pathology:
- No gross abnormalities were noted for any of the animals when necropsied at the conclusion of the 14-day observation period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study, the acute oral LD50 of PTSA is greater than 2000 mg/kg of body weight in female rats.
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