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EC number: 202-443-7
CAS number: 95-71-6
4 out of 10 animals in the 300 mg / kg group
died during pregnancy (15-22 days gestation) and this resulted in a low
birth rate. In addition, 1 female died from the group during the nursing
phase. Also, low levels of corpora lutea were noted, and thus a tendency
to low levels of implantation and live births. The female experimental
animals showed no abnormalities in general findings, body weight or
feeding quantity before the mating phase. A negative effect of the test
substance on the stated values during ovulation (14-21 days of
application) does not seem likely. Therefore, it is assumed that the
test substance has caused a reduction of the oocytes (low values of
corpora lutea). A reduction of implantations relative to corpora lutea
or live births to implantations could not be detected, thus excluding
negative impact on implantation or pregnancy. During the nursing phase,
1 case occurred in which offspring of a dam of the 300 mg / kg group
died. Normal nursing behavior was observed on the day of birth, but it
is believed that at this time the mother already suffered from
circulatory problems due to myocardial degeneration, so that it is
assumed that the situation thereafter rapidly deteriorated,
resulting in impaired breastfeeding ability
and thus death of all descendants resulted. Further changes in oestrus
cycle, mating rate, conception rate, gestation time or birth due to the
test substance could not be determined. The deaths of all offspring of a
dam lead to low values of non-dead offspring and the 4 -day survival
rate. Other changes in live birth rate, general findings, examination of
body surface area, body weight and autopsy, which could be attributed to
the test substance, could not be determined.
This gives the following NOEL and NOEAL for
2,3,5-trimethylhydroquinone under the given experimental conditions. The
NOEL and NOEAL for repeated-dose toxicity in males is 10 mg / kg / day
because of death in the 300 mg / kg group and elevated levels of
hemosiderin dye in the spleen in the 60 mg /kg group were found. In
females, the value is 60 mg / kg / day since deaths and increased levels
of hemosiderin dye in the spleen were noted in the 300 mg / kg group.
Concerning. Reproductive toxicity of NOEL and NOEAL in males is 300 mg /
kg / day, as no change could be detected. In dams and the F1 generation,
the value is 60 mg / kg / day as low rates of birth rate, corpus luteum,
offspring and one death of all offspring of
a dam were found.
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