Registration Dossier
Registration Dossier
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EC number: 222-212-4 | CAS number: 3387-41-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 442D (In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method)
- GLP compliance:
- yes
- Type of study:
- other: LuSens Test
- Key result
- Parameter:
- other: relative viability
- Value:
- 70
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Conclusions:
- Under the experimental conditions of this study, the test item, Thuj-4(10)-ene, was nega-tive in the LuSens assay and is therefore considered not having the potential to activate the Nrf2 transcription factor. However, due to the low test item concentrations (highest concentrations < 1000 µM), the result has to be considered as inconclusive in accordance to the OECD 442D.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Justification for classification or non-classification
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