Registration Dossier
Registration Dossier
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EC number: 946-732-2 | CAS number: -
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Liquidambar Styraciflua, oil
- EC Number:
- 946-732-2
- IUPAC Name:
- Liquidambar Styraciflua, oil
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA:J
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 25%, 50%, 100%
- No. of animals per dose:
- 4
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
- Positive control results:
- SI value for positive control group was 4.1
In vivo (LLNA)
Resultsopen allclose all
- Key result
- Parameter:
- EC3
- Value:
- 58.33
- Key result
- Parameter:
- SI
- Value:
- 3.5
- Test group / Remarks:
- 100%
- Parameter:
- SI
- Value:
- 2.9
- Test group / Remarks:
- 50%
- Parameter:
- SI
- Value:
- 1.8
- Test group / Remarks:
- 25%
Applicant's summary and conclusion
- Interpretation of results:
- other: weak sensitizing
- Conclusions:
- Under the experimental conditions of the present study, the test item induce contact sensitization for mice in the Local Lymph Node Drainage test.
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