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EC number: 822-547-1
CAS number: 906673-54-9
The objective of this study was to evaluate PF-06932437 for its ability
to induce skin corrosion on a human three dimensional epidermal model
(EpiDerm (EPI-200)). The possible corrosive potential of PF-06932437
was tested through topical application for 3 minutes and 1 hour. The
study procedures described in this report were based on the most recent
OECD and EC guidelines. Groton batch GR12302 of PF-06932437 was an
off-white powder. Skin tissue was moistened with 25 µL of Milli-Q water
and at least 25 mg of PF-06932437 was applied directly on top of the
skin tissue. The positive control had a mean relative tissue viability
of 7.9% after the 1-hour exposure. The absolute mean OD570 (optical
density at 570 nm) of the negative control tissues was within the
acceptance limits of OECD 431 (lower acceptance limit ≥0.8 and upper
acceptance limit 2.8) and the laboratory historical control data range.
In the range of 20 - 100% viability the Coefficient of Variation
between tissue replicates was 10%, indicating that the test system
functioned properly. Skin corrosion is expressed as the remaining cell
viability after exposure to the test item. The relative mean tissue
viability obtained after 3-minute and 1-hour treatments with the test
item compared to the negative control tissues was 99% and 98%,
respectively. Because the mean relative tissue viability for
PF-06932437 was not below 50% after the 3-minute treatment and not below
15% after the 1-hour treatment PF-06932437 is considered to be not
corrosive. In conclusion, PF-06932437 is not corrosive in the in vitro
skin corrosion test under the experimental conditions described in this
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