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EC number: 822-547-1
CAS number: 906673-54-9
The objective of the study was to evaluate PF-06932437 for its ability
to adversely affect aerobic microbial treatment plants and, if possible,
to determine the EC50 and/or the no - observed effect concentration
(NOEC). The influence of PF-06932437 on the respiration rate of
activated sludge was investigated after a contact time of 3 hours. The
study procedures described in this report were based on the OECD
guideline No. 209, 2010. The batch of PF-06932437 tested was an
off-white powder with a purity of 98.7%. A correction was made for the
purity of the test item. A correction factor of 1.013 was used. All
further concentrations reported are based on the pure test item.
Preparation was as much as possible performed under low light
conditions. The test item was not sufficiently soluble to allow
preparation of an aqueous solution at a concentration of 10 g/L.
Therefore, weighed amounts were added to the test bottles containing
Milli-RO water. The test item – Milli-RO water mixtures were
magnetically stirred for a short period and subsequently, synthetic
medium, sludge and Milli - RO water were added resulting in the required
concentrations. Optimal contact between the test item and test medium
was ensured by applying continuous aeration and stirring during the 3
hour exposure period. Thereafter, oxygen consumption was recorded for
approximately 10 minutes. The final test was performed based on the
result of a preceding combined limit/range-finding test. Five
concentrations were tested, ranging from 46 to 1000 mg/L and increasing
with a factor 2.2. Five replicates per concentration and six replicates
for an untreated control group were tested. No statistically significant
inhibition of the respiration rate of the sludge was recorded at 100 mg
PF-06932437 per liter. At higher concentrations the inhibitory effect
of PF-06932437 on aerobic waste water (activated sludge) bacteria
increased with increasing concentration, ranging from 9 % inhibition at
220 mg/L to 13% at 1000 mg/L. The batch of activated sludge was tested
for sensitivity with the reference item 3,5-dichlorophenol, and showed
normal sensitivity. The study met the acceptability criteria prescribed
by the study plan and was considered valid. PF-06932437 was not toxic to
waste water (activated sludge) bacteria at a concentration of 100 mg/L
(NOEC). The effect parameters for the inhibition of the respiration rate
are presented below.
PF-06932437 Concentration (mg/L)
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