Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 285-480-1
CAS number: 85099-25-8
No specific study was
performed on the absorption, distribution, metabolism, excretion (ADME)
of this substance (WS400301), but data are currently available fromin
substance, WS400301, is the salt of dimethylcyclohexanamine and
phosphoric acid with molecular weights of 127 Da and 98 Da,
respectively. The substance is well water soluble (> 1000 g/L) and
accordingly has low lipophilicity (Log10Pow for dimethylcyclohexanamine
ranges from < 1 to 4.1 between pH values from 4 to 9, respectively).
expected (and was confirmed in bridging studies) that the salt
dissociates in aqueous environments. Accordingly, exposure of man and
the environment will be to phosphate ions and dimethylcyclohexanamine.
inorganic phosphate salts are used as direct food additives, e.g. E 339,
340, 341, 343, because of their low toxicological potential. Therefore,
any adverse effects of WS400301 will be based on toxic properties of
exposure to WS400301 absorption of dimethylcyclohexanamine and systemic
distribution is to be expected based on the low molecular weight and
high water solubility. In the repeat dose feeding study with the
read-across source substance dimethylcyclohexanamine some effects on
organ weights (not considered as adverse) were observed indicating
systemic distribution. At the highest dose level very likely
palatability reasons lead to reduced food intake and body weight gain.
acute oral toxicity study performed in rats with the read-across source
substance, i.e. dimethylcyclohexanamine, the LD50 was derived at a dose
of approx. 290 mg/kg body weight. This value very likely was based not
only on oral exposure to the substance but also was due to corrosive and
irritating effects caused by dimethylcyclohexanamine as was observed in
the stomach of dead animals (which in addition enhanced systemic
availability of the substance).
availability of WS400301 after dermal application is expected to be low
based on its hydrophilicity. However, in the acute dermal toxicity study
performed with the read-across source substance dimethylcyclohexanamine
relatively high toxicity (LD50 380 mg/kg) was observed. It is rather
likely that this dermal toxicity was (also) due to severe corrosivity of
dimethylcyclohexanamine observed after 24 hour occlusive exposure
animals (which in addition enhanced systemic availability of the
of WS400301 under a vapour state will be very limited, because of its
low vapour pressure (0.01 Pa at 20°C) and because it is a viscous liquid
substance limiting its availability as an inhalable aerosol.
There is no
information on metabolism and excretion of WS400301.
of WS400301 is very unlikely based on the high hydrophilicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Sellel veebilehel kasutatakse küpsiseid, et tagada lehe parim kasutus.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again