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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Refer to analogue justification provided in IUCLID section 13.
Reason / purpose for cross-reference:
read-across source
Duration:
3 h
Dose descriptor:
EC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks on result:
other: Source: CAS 37266-93-6, Giarei, 2016, activated sludge microorganisms

Description of key information

EC50 (3 h) > 1000 mg/L (nominal, OECD 209); read-across

Key value for chemical safety assessment

EC50 for microorganisms:
1 000 mg/L

Additional information

No experimental study is available investigating the toxicity of Fatty acids C16-18 (even numbered), mono and diesters with sucrose (no CAS) to activated sludge microorganisms. Therefore, in accordance with Article 13 (1) of Regulation (EC) No 1907/2006, "information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met.” Having regard to the general rules for grouping of substances and read-across approach laid down in Annex XI, Item 1.5, of Regulation (EC) No 1907/2006“Grouping of substances and read across” and in accordance with the read across assessment framework (RAAF, ECHA 2017),read-across from good quality data of an analogue substance was performed.

The available study with the source substance Sucrose Laurate was performed according to OECD 209 (GLP) with activated sludge of a predominantly domestic sewage. Three concentrations (10, 100 and 1000 mg/L) were tested. The respiration rate was measured after 3 h of exposure and compared to the control. Inhibition of respiration was recorded (5.9% at 10 mg/L, 7.3% at 100 mg/L and 19.5% at 1000 mg/L). No EC10/NOEC-value was derived in the study. However, 50% inhibition of respiration was not recorded allowing for a derivation of an EC50 (3 h) > 1000 mg/L. 

Based on the available result from one structurally related analogue substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that the target substance will exhibit effects on activated sludge microorganisms in the same range.