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EC number: 254-663-8 | CAS number: 39872-57-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 - 21 Jul 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Staatliches Gewerbeaufsichtsamt Hildesheim, Germany
- Type of method:
- flask method
- Key result
- Water solubility:
- 119 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 6.6
- Conclusions:
- A water solubility value of 119 mg/L (at 20 °C, pH = 6.6) was determined for the test substance according to OECD 105.
- Executive summary:
The water solubility of test item was determined according to OECD guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6. The Study was performed under GLP. The solubility of the test item was determined using the flask method at 20 ± 0.5 °C with pre-incubation at 30 ± 0.5 °C and the concentrations were verified by GC-MS. The solubility was measured to be 119 mg/L at 20 °C, pH = 6.6.
Reference
Check of the temperature
Temperature at Pre-Incubation (30 °C) and Thermostatisation Phase (20 °C) (measured hourly)
Intended temperature [°C] |
Measured temperature. [°C] |
||
|
min. |
max. |
Mean value ± SD |
30.0 ± 0.5 |
29.96 |
30.08 |
30.01 ± 0.03 |
20.0 ± 0.5 |
19.96 |
20.02 |
19.99 ± 0.01 |
Check of the pH-Value
The pH-values were determined with the remaining test item mixtures in the original test vessels, which were kept constant at 20 ± 0.5 °C.
Test temperature [°C] |
Pre-incubation time [h] |
Replicate |
Measured pH |
Mean value |
20 |
24 |
1 |
6.412 |
6.6 |
2 |
6.398 |
|||
48 |
1 |
6.888 |
||
2 |
6.579 |
|||
72 |
1 |
7.008 |
||
2 |
6.589 |
|||
Control |
7.616 |
- |
Check of the Tyndall-Effect
No Tyndall-Effect was observed in any of the test vessels
Water Solubility Results
No significant signals were obtained for the control sample.
The water solubility results at 20 °C for the test item are reported in the following table.
Preincubation time |
Replicate No. |
Concentration (1) [mg/L] |
Mean [mg/L] |
24 h |
1 |
112 |
115 |
2 |
117 |
||
48 h |
1 |
118 |
120 |
2 |
122 |
||
72 h |
1 |
124 |
123 |
2 |
123 |
||
Mean (24 - 72 h) |
|
|
119 |
Deviation [%] (24 - 72 h) |
|
|
7.5 |
(1) Dilution factor of 1000 and exact weight of the standard taken into account
Conclusion
The solubility of the test item was determined at 20 ± 0.5 °C to be 119 mg/L (pH 6.6).
Description of key information
Water solubility: 119 mg/L at 20 °C, pH = 6.6 (OECD 105, flask method)
Key value for chemical safety assessment
- Water solubility:
- 119 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of test item was determined according to OECD guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6. The Study was performed under GLP. The solubility of the test item was determined using the flask method at 20 ± 0.5 °C with pre-incubation at 30 ± 0.5 °C and the concentrations were verified by GC-MS. The solubility was measured to be 119 mg/L at 20 °C, pH = 6.6.
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