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EC number: 230-603-6
CAS number: 7216-56-0
In an acute oral toxicity study performed
according to Guideline OECD 423 and in compliance with GLP, a single
dose of 2000 mg/kg bw of the test substance was given by oral gavage to
a group of 6 female Wistar rats. Animals were then observed for
mortality and clinical signs of toxicity for 14 days.
No mortality occurred during the study. A
decrease or an absence in spontaneous activity (3/6), Preyer’s reflex
(3/6), muscle tone (3/6), righting reflex (2/6), associated with an
increase in salivation (2/6), a hypothermia (1/6), myosis (1/6), eyes
partly closed (3/6), dyspnea (3/6) and piloerection (3/6) were observed.
The animal recovered a normal activity on Day 7. The body weight
evolution of the animals revealed an absence of body weight gain on Day
2 versus Day 0. The body weight evolution was as expected from Day 7.
The macroscopic examination of the animals at the end of the study
revealed a thickening and yellow coloration of the forestomach.
Therefore, the oral LD50 of the test
substance is >2000 mg/kg bw in rats. Therefore it is not classified
according to Regulation (EC) No 1272/2008 and GHS regulation. No signal
word or hazard statement is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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