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EC number: 230-603-6
CAS number: 7216-56-0
In an acute oral toxicity study performed
according to Guideline OECD 423 and in compliance with GLP, a single
dose of 2000 mg/kg bw of the test substance was given by oral gavage to
a group of 6 female Wistar rats. Animals were then observed for
mortality and clinical signs of toxicity for 14 days.
No mortality occurred during the study. A
decrease or an absence in spontaneous activity (3/6), Preyer’s reflex
(3/6), muscle tone (3/6), righting reflex (2/6), associated with an
increase in salivation (2/6), a hypothermia (1/6), myosis (1/6), eyes
partly closed (3/6), dyspnea (3/6) and piloerection (3/6) were observed.
The animal recovered a normal activity on Day 7. The body weight
evolution of the animals revealed an absence of body weight gain on Day
2 versus Day 0. The body weight evolution was as expected from Day 7.
The macroscopic examination of the animals at the end of the study
revealed a thickening and yellow coloration of the forestomach.
Therefore, the oral LD50 of the test
substance is >2000 mg/kg bw in rats. Therefore it is not classified
according to Regulation (EC) No 1272/2008 and GHS regulation. No signal
word or hazard statement is required.
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