Triethyl O-acetylcitrate

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

presumably 1974

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Methodical details are missing

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Reference 2

Reference Type:

publication

Title:

Final Report on the Safety Assessment of Acetyl Triethyl Citrate, Acetyl Tributyl Citrate, Acetyl Trihexyl Citrate, and Acetyl Trioctyl Citrate

Author:

Cosmetic Ingredient Review

Year:

2002

Bibliographic source:

International Journal of Toxicology, 21(Suppl. 2):1–17

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

3 male albino rabbits were used. 0.1 mL was instilled once into the left conjunctival sac, while the right eyes were used as controls. Observations were made at 20 min and at 3 – 72 h after application.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Triethyl O-acetylcitrate

EC Number:

201-066-5

EC Name:

Triethyl O-acetylcitrate

Cas Number:

77-89-4

Molecular formula:

C14H22O8

IUPAC Name:

triethyl 2-acetoxypropane-1,2,3-tricarboxylate

Test animals / tissue source

Species:

rabbit

Strain:

other: Albino

Details on test animals or tissues and environmental conditions:

no data

Test system

Vehicle:

not specified

Controls:

other: right eyes were used as controls

Amount / concentration applied:

0.1 mL

Duration of treatment / exposure:

single application

Observation period (in vivo):

Observations were made at 20 min and at 3 – 72 h after application.

Number of animals or in vitro replicates:

3 m

Details on study design:

SCORING SYSTEM: no data

Results and discussion

In vivo

Results

Remarks on result:

other: Transient erythema (slight to moderate) of the palpebral conjunctivae was observed in two of the three rabbits. After 24 hours, the erythema was described as negligible.

Any other information on results incl. tables

Transient erythema (slight to moderate) of the palpebral conjunctivae was observed in two of the three rabbits. After 24 hours, the erythema was described as negligible.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

ATEC was slightly eye irritating. However, classification criteria are not meet.

Executive summary:

3 male albino rabbits were used. 0.1 mL was instilled once into the left conjunctival sac, while the right eyes were used as controls. Observations were made at 20 min and at 3 – 72 h after application. Transient erythema (slight to moderate) of the palpebral conjunctivae was observed in two of the three rabbits. After 24 hours, the erythema was described as negligible.