α-D-glucose pentaacetate

Boiling point

Administrative data

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

05 May - 26 September 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7220 (Boiling Point / Boiling Range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

α-D-glucose pentaacetate

EC Number:

210-073-2

EC Name:

α-D-glucose pentaacetate

Cas Number:

604-68-2

Molecular formula:

C16H22O11

IUPAC Name:

1,2,3,4,6-penta-O-acetyl-alpha-D-glucopyranose

impurity 1

Reference substance name:

β-D-glucose pentaacetate

EC Number:

210-074-8

EC Name:

β-D-glucose pentaacetate

Cas Number:

604-69-3

Molecular formula:

C16H22O11

IUPAC Name:

1,2,3,4,6-penta-O-acetyl-beta-D-glucopyranose

impurity 2

Reference substance name:

Water

EC Number:

231-791-2

EC Name:

Water

Cas Number:

7732-18-5

Molecular formula:

H2O

IUPAC Name:

Oxidane

impurity 3

Reference substance name:

Unknown impurities.

Molecular formula:

Not available as unknown impurities.

IUPAC Name:

Unknown impurities.

Test material form:

solid: crystalline

Remarks:

Crystalline powder

Details on test material:

Batch No: 14126200
Storage: at room temperature, protected from light

Results and discussion

Boiling point

Key result

Atm. press.:

1 013 hPa

Decomposition:

yes

Decomp. temp.:

ca. 200 °C

Remarks on result:

other: Boiling of the test item was not observed below the temperature of decomposition, therefore the test item has no boiling temperature.

Any other information on results incl. tables

During the heating phase a distinct endothermic effect was observed in the temperature range of 85 - 120 °C, which can be assigned to the melting of the test item. In the temperature range of 270 – 370 °C a second endothermic effect could be observed. Due to the broad endothermic signal three additional tests by means of the capillary method were performed for a verification of the observations in the DSC:

For this purpose, the capillaries were filled with the test item up to 5 mm height. The capillaries were heated up in the melting point apparatus from 25 to 300 °C with a heating rate of 10 K/min.

At a temperature of 94.7 °C the test item started to melt. At 107.2 °C it was completely molten. At 200.7 °C the colour of the test item changed to light brown, at 226.1 °C to dark brown. At 254.6 °C the test item ascended in the capillaries. At 298 °C the test item was black and the measurements were determined.

Based on these results, it can be stated, that the test item has no boiling point up to 500 °C. It decomposes starting at approx. 200 °C and starts to evaporate at approx. 250 °C.

The detailed results of the DSC-measurements are given in the table in the field 'Overall remarks'.

Applicant's summary and conclusion

Conclusions:

The test item Alpha-D-glucose pentaacetate (CAS no. 604-68-2) has no boiling point up to its decomposition starting at 200 °C at atmospheric pressure (1013 hPa) as determined by differential scanning calorimetry according to Regulation EC No. 440/2008 Method A.2. and OECD Test Guideline 103 (1995). It started to decompose at approx. 200 °C.

Executive summary:

The test item Alpha-D-glucose pentaacetate (CAS no.604-68-2) has no boiling point up to its decomposition starting at 200°C at atmospheric pressure (1013 hPa) as determined by differential scanning calorimetry according to Regulation EC No. 440/2008 Method A.2. and OECD Test Guideline 103 (1995). It started to decompose at approx. 200 °C.