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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11 July 2009 to 30 September 2009
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
other: "The Guidelines for the testing of chemicals" State Environmental Protection Administration (SEPA) of China, No.111
Deviations:
no
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
no
GLP compliance:
yes
Analytical monitoring:
yes
Details on test conditions:
- 0.5 g of test material was added into buffer pH = 4, 7 and 9 and surge for 6 h at 25 ± 1°C. Take off supernatant and centrifuge, and then filtrate through 0.45 µm film. Dilute 10 times for analysis
-Room temperature: 15.5°C
-Relative humidity (RH): 40%
Transformation products:
not specified
Key result
pH:
4
Temp.:
25 °C
Hydrolysis rate constant:
> 0 s-1
DT50:
< 3 h
Key result
pH:
7
Temp.:
25 °C
Hydrolysis rate constant:
> 0 s-1
DT50:
< 3 h
Key result
pH:
9
Temp.:
25 °C
Hydrolysis rate constant:
> 0 s-1
DT50:
< 3 h
Validity criteria fulfilled:
yes
Conclusions:
Under the conditions of this study the test material fully hydrolysed at a rate of >6.4 x 10^-5 s^-1 with a half life time of <3.0 hours.
Executive summary:

The hydrolysis as a function of pH of the test material was investigated using liquid chromatography/mass spectrum. The investigation was performed in accordance with "The Guidelines for the testing of chemicals" State Environmental Protection Administration (SEPA) of China, No. 111 with reference to OECD 111 and under GLP conditions. 0.5 g of test material was placed into buffer of pH 4.0, 7.0 and 9.0 and surged for 6 hours at 25 ± 1°C. The supernatant was removed and centrifuged, and then filtered through a 0.45 µm film. This was then diluted ten times for analysis.

Under the conditions of this study the test material fully hydrolysed at a rate of >6.4 x 105 s-1 with a half life time of <3.0 hours.

Description of key information

Under the conditions of this study the test material fully hydrolysed at a rate of >6.4 x 10-5 s-1 with a half life time of <3.0 hours.

Key value for chemical safety assessment

Half-life for hydrolysis:
3 h
at the temperature of:
25 °C

Additional information

The hydrolysis as a function of pH of the test material was investigated using liquid chromatography/mass spectrum. The investigation was performed in accordance with "The Guidelines for the testing of chemicals" State Environmental Protection Administration (SEPA) of China, No. 111 with reference to OECD 111 and under GLP conditions. 0.5 g of test material was placed into buffer of pH 4.0, 7.0 and 9.0 and surged for 6 hours at 25 ± 1°C. The supernatant was removed and centrifuged, and then filtered through a 0.45 µm film. This was then diluted ten times for analysis.

Under the conditions of this study the test material fully hydrolysed at a rate of >6.4 x 10-5s-1 with a half life time of <3.0 hours.