Registration Dossier
Registration Dossier
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EC number: 204-465-2 | CAS number: 121-33-5
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal, other
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Not enough data for assessment
Data source
Referenceopen allclose all
- Reference Type:
- other:
- Title:
- No information
- Year:
- 1 990
- Bibliographic source:
- BIBRA Toxicity Profile Vanilline 121-33-5
- Reference Type:
- publication
- Title:
- Problem of the toxicity of vanillin
- Author:
- Makaruk MI
- Year:
- 1 980
- Bibliographic source:
- Gig Sanit, 6, 78-80
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Vanillin
- EC Number:
- 204-465-2
- EC Name:
- Vanillin
- Cas Number:
- 121-33-5
- Molecular formula:
- C8H8O3
- IUPAC Name:
- 1-butoxypropan-2-ol
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on exposure:
- no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 10 days
- Frequency of treatment:
- daily
Doses / concentrations
- Dose / conc.:
- 408 mg/kg bw/day
- No. of animals per sex per dose:
- no data
- Control animals:
- yes
- Details on study design:
- no data
- Positive control:
- no data
Examinations
- Observations and examinations performed and frequency:
- no data
- Sacrifice and pathology:
- no data
- Other examinations:
- no data
- Statistics:
- no data
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Dermal irritation:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- effects observed, treatment-related
- Haematological findings:
- effects observed, treatment-related
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- by immersion of 2/3 of the tail in a 5% oil solution:
no death; unchanged aspect and behaviour;
slight loss of body weight; reduction in the number of red blood cells and in the haemoglobin level; affected liver function (as increase in the
barbiturate-induced sleeping time); hypereamia of the liver and spleen.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
