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EC number: 232-800-2
CAS number: 9025-57-4
was assayed for mutation in four histidine-requiring strains of S.
typhimurium, and one tryptophan-requiring strain of E. coli both in the
absence and presence of metabolic activation by a metabolic activation
system (S-9 mix), in two separate experiments. A modified ‘treat and
plate’ methodology was used for all treatments in this study. All
xylanase treatments in this study were performed using formulations
prepared in water for irrigation (purified water).
1 treatments used a final (nominal) concentration of 16, 50, 160, 500,
1600, and 5000µg
TOS/mL Experiment 2 a narrowed concentration intervals were employed
covering the range 160-5000µg
TOS/mL in order to examine more closely those concentrations approaching
the maximum test concentration. Following all treatments there were not
clear evidence of toxicity.
xylanase treatment of all the test strains in the absence and presence
of S-9, no clear and concentration-related increases in revertant
numbers were observed that were≥2-fold
(in strains TA98, TA100 and WP2 uvrA pKM101) or≥3-fold
(in strains TA1535 and TA1537) the concurrent vehicle control. This
study was therefore considered to have provided no evidence of any
xylanase mutagenic activity in this assay system.
on the results obtained in this study and under the assay conditions
applied, it is concluded that xylanase is not mutagenic in the Ames test.
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