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EC number: 232-800-2
CAS number: 9025-57-4
repeated dose oral toxicity study was a subchronic toxicity test
conducted according to OECD guideline 408 (revised 1998), and in
compliance with GLP. The purpose of the study was to satisfy regulatory
demands because the enzyme is used for production of food in EU.
conclusion, oral administration (by gavage) of xylanase to rats at
dosages of up to the highest dose level tested, equivalent to 10 mL of
the undiluted test material/kg body weight/day or 1051 mg Total Organic
Solids (TOS)/kg body weight/day for thirteen weeks was well-tolerated
and did not produce any toxicologically significant changes.
the No Observed Adverse Effect Level (NOAEL) was considered to be the
highest dose level administered, equivalent to 10 mL xylanase/kg body
weight/day or 1051 mg Total Organic Solids (TOS)/kg body weight/day.
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