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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
February - March 1982
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Acute toxicity LD50 range finding study
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(E)-methyl non-2-enoate
EC Number:
811-711-8
Cas Number:
14952-06-8
Molecular formula:
C10H18O2
IUPAC Name:
(E)-methyl non-2-enoate
Test material form:
liquid

Test animals

Species:
mouse
Strain:
other: SPF albino Fu
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
1000, 2000, 4000, 8000 mg/kg
No. of animals per sex per dose:
10
Control animals:
yes

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
>= 8 000 mg/kg bw
Based on:
test mat.
Mortality:
0 deaths occured
Clinical signs:
Principal toxic effect:  reduced breathing rate @ 8 g/kg

Any other information on results incl. tables

After 1000 to 4000 mg/kg (oral) the animals cannot be distinguished from the controls. At 8000, the breathing rate is reduced, control appearance being regained by the 24th hour after administration.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

It was concluded that the LD50 of Neofolione was greater than 8000 mg/kg/bw.