Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Oral: OECD 425; rat LD50 was >5000 mg/kg. Reliability = 1
Dermal: OECD 402; rat LD50 was >5000 mg/kg. Reliability = 1
Inhalation: OECD 403; rat LC50 was >5.06 mg/L (>5060 mg/m3). Reliability = 1
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- OECD Guideline, GLP study
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 5 060 mg/m³
- Quality of whole database:
- OECD Guideline, GLP study
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- OECD Guideline, GLP study
Additional information
The test substance has low oral, inhalation, and dermal toxicity in the rat. The rat oral and dermal LD50s were >5000 mg/kg body weight. The only clinical sign observed was reduced faecal volume in one rat on Day 1 of the oral study. No other effects in clinical signs, body weight, or gross necropsy were observed in either study. The rat 4-hour inhalation LC50 was >5.06 mg/L, the highest concentration tested. Following exposure, all animals exhibited irregular respiration, but recovered by Day 2. Some rats exhibited weight loss on day 1. No other effects were observed during the study or at gross necropsy.
Justification for classification or non-classification
Based on oral and dermal LD50s in rats of >5000 mg/kg, and a 4-hour inhalation LC50 in rats of >5.06 mg/L, no classification is required for acute toxicity endpoints according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
