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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study; non-GLP

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Petrocquimia Espanola
Year:
1984
Bibliographic source:
Acute oral toxicity to Rats of PETREPAR n-C13 (C14)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetradecane
EC Number:
211-096-0
EC Name:
Tetradecane
Cas Number:
629-59-4
Molecular formula:
C14H30
IUPAC Name:
tetradecane
Details on test material:
1-Tetradecane (PETREPAR n-C14) , 95% purity

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
single dose of 5000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
not specified
Mortality:
No deaths occurred during the course of the study.
Clinical signs:
other: Piloerection was observed shortly after dosing in all animals. Recovery, as judged by external appearance and behavior, was apparently complete by day 3
Gross pathology:
Terminal necropsy findings were normal.
Other findings:
No deaths occurred during the course of the study. Piloerection was observed shortly after dosing in all animals. Recovery, as judged by external appearance and behavior, was apparently complete by day 3. Terminal necropsy findings were normal.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute lethal oral dose to rats of the test material was found to be > 5.0 g/Kg bodyweight
Executive summary:

The acute lethal oral dose to rats of the test material was found to be > 5.0 g/Kg bodyweight