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EC number: 229-745-1
CAS number: 6701-13-9
historical control data
Body weight (mean (± SD))
. Day 1
236 (± 8.9)
233 (± 8.1)
362 (± 12.0)
352 (± 7.9)
. Day 8
253 (± 12.0)
250 (± 8.2)
394 (± 15.3)
383 (± 9.6)
. Day 15
273 (± 16.3)
275 (± 8.4)
441 (± 21.5)
430 (± 14.9)
Body weight change (mean (± SD))
. Days 1-8
+17 (± 11.0)
+18 (± 8.6)
+32 (± 9.1)
+31 (± 3.6)
. Days 8-15
+20 (± 7.1)
+25 (± 2.8)
+47 (± 7.5)
+47 (± 7.2)
. Days 1-15
+37 (± 16.3)
+42 (± 6.5)
+79 (± 15.6)
+78 (± 9.5)
The objective of this study was to
evaluate the potential toxicity of 1,10-decanediol diacrylate following
a single dermal application to rats.
This study was conducted in compliance
with OECD Guideline No. 402 and the principles of Good Laboratory
The test item was applied in its
original form to the skin of five female then five male Sprague-Dawley
rats at the dose-level of 2000 mg/kg. The application site was covered
by a semi-occlusive dressing for 24 hours.
Each animal was observed at least once
a day for mortality and clinical signs for 15 days. From day 2, any
local reactions at the treatment site were also noted. Body weight was
recorded on day 1 and then on days 8 and 15.
On completion of the observation
period, the animals were sacrificed and then submitted for a macroscopic post-mortem
examination.Macroscopic lesions were preserved in buffered formalin
then destroyed at the finalization of the study report as no microscopic
examination was performed.
No unscheduled deaths occurred during
No clinical signs indicative of
systemic toxicity were observed in any animals.
Erythema and edema were noted on
application site of all male and female animals from day 2 up to day 7
at the latest. These findings were associated with dryness of the skin
at application site of all males and at application site of 4/5 females
from day 4 up to day 15 at the latest.
In addition, desquamation was noted in
2/5 females from day 4 to day 13 or 14.
Scabs on application site were also
observed in 1/5 males and 1/5 females between day 5 and day 7.
Body weight of
animals was unaffected by the test item treatment when compared to
historical control data.
The test item administration did not
induce any macroscopic findings at necropsy.
Under the experimental conditions of
this study, the dermal LD50 of 1,10-decanediol diacrylate was higher
than 2000 mg/kg in rats.
Therefore, the test item should not be
classified as harmful or toxic by dermal route according to the criteria
of CLP Regulation.
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