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EC number: 229-745-1
CAS number: 6701-13-9
No experimental toxicokinetic study is available on 1,10-decanediol dimethacrylate. However, as per REACH guidance document R7.C (2014), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties.Based on the toxicological data and the physicochemical properties, the absorption of 1,10-decanediol dimethacrylate is expected to be low by oral route, dermal route and inhalation.
experimental toxicokinetic study is available on 1,10-decanediol
dimethacrylate. However, as per REACH guidance document R7.C (2014),
information on absorption, distribution, metabolism and excretion may be
deduced from the physicochemical properties, including:
molecular weight: 310 g/mol
solubility: 138,6 µg/L (20°C) (insoluble)
coefficient Log Kow: > 6.5
pressure: 0.0329 Pa (25°C)
high value of log Kow (>6,5) and the low solubility (< 1 mg/L) of
1,10-decanediol dimethacrylate are favourable for a low oral absorption.
Indeed, no clinical effects or mortality were observed after one single
administration (5000 mg/kg) of 1,10 -decanediol dimethacrylate by gavage
(oral route) in rats.
oral absorption is expected to be low for 1,10 -decanediol
dimethacrylate; the worst case value for oral absorption was taken into
a solubility < 1 mg/L, dermal absorption is anticipated to be low. A
high value of Log Kow suggests that the rate of penetration of the
substance may be limited by the rate of transfer between the stratum
corneum and the epidermis. However, a molecular mass smaller than 500
g/mol are favourable to a dermal absorption. The methacrylates are known
to bind to skin components, and this binding decreases their dermal
absorption. Indeed, thedermal absorption of 1,10 -decanediol
dimethacrylate is anticipated to be low. The low dermal absorption
can be confirmed in the dermal acute toxicity study, where no major
systemic effect or mortality were observed in rats treated with 2000
mg/kg bw. However, 1,10 -decanediol dimethacrylate showed allergic
reaction in the LLNA: it is evidence that some uptake must have occurred
although it may only have been a small fraction of the applied dose. The
worst case value for dermal absorption was taken into account: 10%
on the low value of the vapour pressure (<0.1 Pa), 1,10 -decanediol
dimethacrylate is not considered as a volatile substance. Moreover, theabsorption
by inhalation can be expected to be low for 1,10 -decanediol
dimethacrylatebased on the values of water solubility and log kow.The
worst case value for inhalation absorption was taken into account: 100%
No specific data is
available on the distribution or metabolism of 1,10 -decanediol
dimethacrylate. No organ toxicity was showed in the studies.
Due to the low water
solubility and the low molecular mass, the excretion of 1,10 -decanediol
dimethacrylate in the urines is expected to be low. An excretion via
bile and faeces is possible.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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