Registration Dossier
Registration Dossier
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EC number: 200-926-7 | CAS number: 76-02-8
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- not specified
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Justification for type of information:
- Adequacy of study: There is only the result without data, it is impossible to judge of the validity of this study. In a worst case approach, the result has been taken into account for the evaluation.
Cross-reference
- Reason / purpose for cross-reference:
- other: Reference to same publication
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- not specified
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Justification for type of information:
- Adequacy of study: There is only the result without data, it is impossible to judge of the validity of this study, therefore the result was not taken into account for the evaluation.
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
- Test type:
- other: no data
- Species:
- rat
- Details on test animals or test system and environmental conditions:
- No data
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data
- Doses:
- No data
- No. of animals per sex per dose:
- No data
- Details on study design:
- No data
- Dose descriptor:
- LD50
- Effect level:
- 600 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute LD50 value in rats by oral route of Trichloroacetyl chloride is 600 mg/kg.
- Executive summary:
The acute LD50 value in rats by oral route of Trichloroacetyl chloride is 600 mg/kg.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicometric parameters of industrial toxic chemicals under single exposure
- Author:
- Izmerov, N.F. et al
- Year:
- 1 982
- Bibliographic source:
- CIP, Moscow, USSR
- Reference Type:
- review article or handbook
- Title:
- Trichloroacetyl chloride
- Author:
- Lewis R.J.
- Year:
- 1 995
- Bibliographic source:
- Sax’s Dangerous Properties of Industrial Materials, 9th ed, Van Nostrand Reinhold, New York page 3230
- Reference Type:
- review article or handbook
- Title:
- Trichloroacetyl chloride
- Author:
- Gangolli S.
- Year:
- 1 999
- Bibliographic source:
- The dictionary of substances and their effects (DOSE) - Second edition, page 352
Materials and methods
- Principles of method if other than guideline:
- No data
Test material
- Reference substance name:
- Trichloroacetyl chloride
- EC Number:
- 200-926-7
- EC Name:
- Trichloroacetyl chloride
- Cas Number:
- 76-02-8
- Molecular formula:
- C2Cl4O
- IUPAC Name:
- trichloroacetyl chloride
- Test material form:
- liquid
- Details on test material:
- No data available
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Duration of exposure:
- 4 h
Results and discussion
Effect levels
- Dose descriptor:
- LC50
- Effect level:
- 0.475 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 based on GHS criteria
- Conclusions:
- The acute LC50 (4 hours) value in rats by inhalation route of Trichloroacetyl chloride is 0.475 mg/L.
- Executive summary:
The acute LC50 (4 hours) value in rats by inhalation route of Trichloroacetyl chloride is 0.475 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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