Registration Dossier
Registration Dossier
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EC number: 202-334-4 | CAS number: 94-46-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance Raw Materials Monographs: 3-methylbutyl benzoate
- Author:
- Weir
- Year:
- 1 979
- Bibliographic source:
- A Collection of Monographs Originally Appearing in Food and Cosmetics Toxicology, 1979, Pages 78
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity study of 3-methylbutyl benzoate orally.
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- Isopentyl benzoate
- EC Number:
- 202-334-4
- EC Name:
- Isopentyl benzoate
- Cas Number:
- 94-46-2
- Molecular formula:
- C12H16O2
- IUPAC Name:
- isopentyl benzoate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Isoamyl benzoate (3-methylbutyl benzoate)
- Molecular formula: C12H16O2
- Molecular weight: 192.256 g/mole
- Substance type: Organic
- Physical state: Liquid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 6330 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 6 330 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50 % mortality was observed in treated rats at 6330 mg/kg bw
- Clinical signs:
- No data available
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be 6330 mg/kg bw when rats were treated with 3-methylbutyl benzoate orally.
- Executive summary:
In a acute oral toxicity study, rat were treated with 3-methylbutyl benzoate in the concentration of 6330 mg/kg bw. 50 % mortality was observed in treated rats at 6330 mg/kg bw. Therefore, LD50 was considered to be 6330 mg/kg bw when rats were treated with 3-methylbutyl benzoate orally.
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