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Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-12-03 to 2018-12-17
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
GLP compliance:
no
Type of method:
capillary method

Test material

Constituent 1
Chemical structure
Reference substance name:
5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile
EC Number:
811-889-7
Cas Number:
1350653-26-7
Molecular formula:
C14 H8 F2 N4
IUPAC Name:
5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile
Test material form:
solid

Results and discussion

Melting / freezing point
Key result
Melting / freezing pt.:
116.7 °C
Atm. press.:
1 013 hPa

Any other information on results incl. tables

The determination of the melting point was performed by visual judgement using the capillary method. In the preliminary tests the test item starts melting at 115 °C.

The test item showed all five stages of melting. The melting started at 114.8 °C (stage A). At 116.7 °C the last stage E of melting (final Stage of melting, there are no solid particles) could be visual observed. At the end of the test the test item was liquid and dark brown.

Applicant's summary and conclusion

Conclusions:
In conclusion, the test item Fluorpyridonitril melted in the range of 114.8 °C to 116.7 °C (388.0 K to 389.9 K).
Executive summary:

Title: Fluorpyridonitril: Determination of the Melting Point / Melting Range

Purpose:

The purpose of this study was to evaluate the melting point or melting range of Fluorpyridonitril by the capillary method using an electronic controlled heating system.           

Guidelines/Recommendations:

This study was based on the procedures indicated by the following internationally accepted methods:

Commission Regulation (EC) No 440/2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) (originally published as Council Regulation (EC) No 440/2008, corrigendum according to Official Journal of the European Union (EN) dated June 3, 2008, L 143/55), Annex V, Part A, A.1.: “Melting /Freezing Temperature”, Official Journal of the European Union, L 142, Volume 51, 31 May 2008

Organization for Economic Co-operation and Development (OECD), Guidelines for Testing of Chemicals, Guideline No.: 102, “Melting Point/Melting Range”, adopted July 27, 1995

Product Properties Test Guideline of the United States Environment Protection Agency (EPA), OPPTS 830.7200 Melting Point / Melting Range, March 1998

Results:

The determination of the melting point was performed by visual judgement using the capillary method. In the preliminary tests the test item starts melting at 115 °C.

The test item showed all five stages of melting. The melting started at 114.8 °C (stage A). At 116.7 °C the last stage E of melting could be visual observed (for details see Table 1). At the end of the test the test item was liquid and dark brown.

Conclusion: In conclusion, the test item Fluorpyridonitril melted in the range of 114.8 °C to 116.7 °C (388.0 K to 389.9 K).

This study is classified acceptable and satisfies the guideline requirements for melting point studies.