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EC number: 257-055-0
CAS number: 51202-86-9
Six rabbits were emploeyed to determine the effects of the test item on
the mucous membranes of the eye. 100 mg try powder were applied per eye
to the conjunctival sac. The left eye was treated the right served as
control. The test war performed according to Federal Register Vol. 38,
Nr. 187, S. 27019, 1973.
Observations ere recorded 1, 7, 24, 48 and 72 hours after application
using a magnifying lens. After observation at 24 hours all eyes were
washed using saline. Observations at 48 and 72 hours were made after
instillation of sodium fluorescin solution (0.01%).
Effects wwere scored according to "Appraisal of the Safety of Chemicals
in Foods, Drugs and Cosmetics", FDA, Austin, Texas, S. 51, 1975.
After application of the dry powder the maximum irritation index of 12
was observed after 7 hours.
The slight, transient effects recorded in this study cause by
application of the try powder were considered as mechanical irritation
by solid grains of the test material.
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