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EC number: 257-055-0
CAS number: 51202-86-9
The test substance, a yellow powder, was administered by oral gavage
formulated as a 25% suspension in sesame oil at a single dose of 5.000
mg/kg body weight to 10 female SPF-Wistar-rats (strain: Hoe:WISKf (SPF
71) weighing 190-210g (average weight 201g).
The test system with female rats was chosen, because no differences in
sensitivity between sexes were found in preliminary studies. Food was
withheld from 16 h before to 2 h after dosing.
The observation period following treatment lasted for 14 days. During
this time the animals were weighed weekly, and fed with laboratory diet
ALTROMIN 1324 (Altromin GmbH, Lage/Lippe) and tap water ad libitum.
Animals were kept in plastic cages on woodshaves.
At the end of the observation period the animals were sacrificed after
narcotisation, dissected and examined for macroscopically visible
The study was performed between 1 September 1977 and 16 September 1977.
None of the 10 rats died after dosing 5000 mg/kg body weight. After
administration the animals showed balance disorder and prone position.
The weight gains during the observation period were normal in all the
rats. After administration the excreted feces showed a yellow
discoloration. The animals killed at the end of the observation period
showed no macroscopically visible changes.
Due to the experimental design an exact determination of the LD 50 was
not possible. However the median lethal dose (LD50) after single oral
administration to female rats is definitely greater than 5000 mg/kg body
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