Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 611-880-6 | CAS number: 5976-55-6
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification
- Justification for type of information:
- QSAR prediction
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- Unnamed
- Year:
- 2 016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May/July2008
- GLP compliance:
- not specified
Test material
- Reference substance name:
- (17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl acetate
- EC Number:
- 611-880-6
- Cas Number:
- 5976-55-6
- Molecular formula:
- C21H28O3
- IUPAC Name:
- (17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl acetate
- Test material form:
- solid: crystalline
- Details on test material:
- Test item: estradiol-methyl-ether-acetateCAS No.: 5976-55-6Physical state: white crystalline powderStorage:15-30 °C, protected from light and wet
Constituent 1
Results and discussion
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 74.9 mg/kg bw/day (nominal)
- Based on:
- other: Database: Repeated Dose Toxicity (HESS)
- Basis for effect level:
- other: Oral: gavage, rat
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- According to (Q)SAR modell: QSAR Toolbox, the predicted value indicated that estradiol-methyl-ether-acetate causes severe toxic effects (target organ toxicity). The result meets the requirement of STOT-RE Category 2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
