Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-802-7
CAS number: 696-99-1
Acute Dermal Irritation/Corrosion, Evaluation of the skin reaction.
Mean value of all animals.
Skin reaction control:
The shaved area close to the exposure area was employed such as control.
The control area did not show any pathological skin reaction. According
to table 1 of OECD-Guideline 404 at all times of evaluation the value
was classified as 0.
The skin irritation potential of the
test substance was investigated in rabbits (Dr. B. Grunert, 1994,
according to TG OECD 404). The test substance was applied to the skin of
rabbit (skin shaved, substance moistened with water, 0.5 g substance /
animal applied) for 4 hours under occlusive conditions. The study was
performed according to the OECD Guideline 404 with no deviations and
according to the good laboratory practice principles, it is considered
to be of the highest quality (reliability Klimisch 1). The criteria of
validity of the test system are fulfilled. After this period the skin
was evaluated 60 min and daily for 7 days after patch removal. The test
substance produced skin lesions in the form of erythemata and oedemata.
The mean grades of skin reactions were lower than the value classified
as irritant by the European regulation (EC) No. 1272/2008, amending
regulation EC no. 1907/2006 (REACh). When applied to the skin, the test
article may therefore be considered to be non- irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Sellel veebilehel kasutatakse küpsiseid, et tagada lehe parim kasutus.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again