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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March 29 - April 17, 1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Deviations:
not specified
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ammonium (xylenes and 4-ethylbenzene) sulphonate
EC Number:
943-024-5
Molecular formula:
C8H13NO3S
IUPAC Name:
Ammonium (xylenes and 4-ethylbenzene) sulphonate

Test animals

Species:
rat
Strain:
other: COX-SD
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS- Source: Lab Supply Company- Age at study initiation: no data- Weight at study initiation: 195 to 231 grams- Fasting period before study: overnight- Housing: individually in metal, wire-bottomed cages elevated above the droppings- Diet (e.g. ad libitum): ad libitum- Water (e.g. ad libitum): ad libitum- Acclimation period: 7 days minimumENVIRONMENTAL CONDITIONS- Temperature (°C): no data- Humidity (%): no data- Air changes (per hr): no data - Photoperiod (hrs dark / hrs light): no data IN-LIFE DATES: From: March 29, 1979 To: April 17, 1979

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
VEHICLE- Concentration in vehicle: no vehicleMAXIMUM DOSE VOLUME APPLIED: no dataDOSAGE PREPARATION (if unusual): no dataCLASS METHOD (if applicable)- Rationale for the selection of the starting dose: no data
Doses:
4.75 grams and 5.25 grams per kilogram of body weight
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days - Frequency of observations and weighing: observed on day of dosing and daily (5 days per week) for 14 days; weighed on day of dosing and at 7 days post treatment- Necropsy of survivors performed: yes- Other examinations performed: clinical signs including hypoactivity, hypersalivation, diarrhea and diuresis, plus body weight

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 250 mg/kg bw
Based on:
test mat.
Mortality:
none observed
Clinical signs:
other: Nine of the animals (6 at 4.75 g/kg bw and 3 at 5.25 g/kg bw) showed slight to moderate hypoactivity, hypersalivation, diarrhe and diuresis. All nine returned to normal between 24 and 48 hours following dosage.
Gross pathology:
Tissues were not remarkable in any of the animals at sacrifice.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 to male and female rats was greater than 5250 mg/kg body weight.
Executive summary:

The acute Oral Toxicity of Ammonium (xylenes and 4-ethylbenzene) sulfonates was assessed following official method OECD 423, Acute Toxic Class Method. The limit test was performed with a single dose of 5250 mg/kg bw based on test material administered to both males and females Wistar rats.


Nine of the animals (6 at 4.75 g/kg bw and 3 at 5.25 g/kg bw) showed slight to moderate hypoactivity, hypersalivation, diarrhe and diuresis. All effects were reversible between 24 and 48 hours following dosage.


Dissection of animals at the end of the experiment showed no macroscopically visible organ changes.