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EC number: 218-620-7
CAS number: 2206-94-2
A Buehler test was conducted in guinea pigs, to determine the
sensitisation potential of the test material after repeated topical
applications. The undiluted substance was applied topically, on the skin
of 20 healthy guinea pigs, three times a week, for a three week
induction period. Nine days after the first induction dose, a challenge
dose of the test substance at its highest non-irritating concentration
(100%) was applied to a naive site on each guinea pig. Approximately 24
and 48 hours after induction and challenge dose, the animals were scored
for erythema. A similar induction and challenge application regimen with
HCA in mineral oil was followed using an additional ten guinea pigs that
served as concurrent positive controls for the study. Two naive control
groups were maintained under identical environmental conditions and
treated with the test or the positive control substance at challenge
only. None of the 20 test animals showing showed reactions, so based on
the result of the study the substance was not considered to be a skin
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