Registration Dossier
Registration Dossier
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EC number: 204-442-7 | CAS number: 121-00-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
When male human volunteers were given an oral dose of 50 mg tert-butyl-4-methoxyphenol (BHA), 27-77% was excreted in the urine as the glucuronide and urinary metabolites.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - dermal (%):
- 0.004
Additional information
When male volunteers were given an oral dose of 50 mg BHA, tert-butyl-4-methoxyphenol is absorbed from digestive tract and further distributred in the body. it was found that, 27-77% was excreted in the urine as the glucuronide and urinary metabolites. Urinary excretion of BHA was maximal within 17 hr and complete by 48 hr. When human volunteers were given a single oral dose of 14(C)-labelled BHA (approx 0.5 mg/kg bw), 60-70% of the radioactivity was excreted in the urine within 2 days and 80-86.5% by day 11.
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