Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-313-2 | CAS number: 105-60-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- unsuitable test system
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 940
- Report date:
- 1940
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Skin irritation was tested using undiluted test substance or 50% aquaeous solution on the skin of animals ears under occlusive condition for 24 h.
- GLP compliance:
- no
Test material
- Reference substance name:
- ε-caprolactam
- EC Number:
- 203-313-2
- EC Name:
- ε-caprolactam
- Cas Number:
- 105-60-2
- Molecular formula:
- C6H11NO
- IUPAC Name:
- azepan-2-one
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Luran N (E-Caprolactam)
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- no data
- Number of animals:
- 2 for undiluted test substance
2 for 50% aqueous solution
Results and discussion
Any other information on results incl. tables
Application of concentrated undiluted test substance:
mild redness, ear swelling and increasing size of vessels.
Application of 50% aqueous solution: no findings
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Mild redness, ear swelling and increasing size of vessels were observed after application of concentrated undiluted test substance. Application of 50% aqueous solution showed no findings.
- Executive summary:
Skin irritation was tested in rabbits using undiluted test substance or 50% aquaeous solution on the skin of animals ears under occlusive condition for 24 h. 2 rabbits were tested per condition. Results show mild redness, ear swelling and increasing size of vessels after application of concentrated undiluted test substance. Application of 50% aqueous solution showed no findings.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
