Triethoxy(phenyl)silane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Not stated.

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study report which meets basic scientific principles.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VIII.

Author:

Carpenter C.P, Weil C.S & Smyth H.F.

Year:

1974

Bibliographic source:

Toxicology and Applied Pharmacology 28(2): 313-9.

Reference 2

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List V.

Author:

Smyth H.F, Carpenter C.P, Weil C.S & Pozzani U.C

Year:

1954

Bibliographic source:

Arch. Ind. Hyg. Occup. Med.10, 61-68

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Single oral dose toxicity was estimated by the gastric intubation of groups of five non-fasted, Carworth-Wistar male rats, four to five weeks of age and 90 to 120 grams in weight which have been reared in the laboratory own colony and maintained from time of weaning on Rockland rat diet, complete. The dosages were arranged in a logarithmic series differing by a factor of two. Whenever possible, the chemical was administered undiluted. Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range were estimated by the method of Thompson using the tables of Weil.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Triethoxy(phenyl)silane

EC Number:

212-305-8

EC Name:

Triethoxy(phenyl)silane

Cas Number:

780-69-8

Molecular formula:

C12H20O3Si

IUPAC Name:

triethoxy(phenyl)silane

Test animals

Species:

rat

Strain:

other: Carworth-Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Mellon Institute of Industrial Research, Pennsylvania, USA.
- Age at study initiation: 4-5 weeks.
- Weight at study initiation: 90-120 g (males)
- Diet : Maintained from time of weaning on Rockland rat diet, complete.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

No data

Doses:

No details given

No. of animals per sex per dose:

5

Control animals:

not specified

Details on study design:

No data

Statistics:

No data

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

2 802 mg/kg bw

Based on:

test mat.

Mortality:

No data

Clinical signs:

other: No data

Gross pathology:

No data

Any other information on results incl. tables

The LD50 of 2.83 ml/kg bw (2.05 - 3.89 ml/kg bw) was converted using a specific density of 0.99 g/cm³.

Applicant's summary and conclusion

Interpretation of results:

other: CLP/EU GHS criteria are not met, no classification required according to Regulation (EC) No 1272/2008

Conclusions:

The very limited details given in the secondary source indicate the test substance to be of relatively low toxicity via the oral route.