Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

No data are available for the carcinogenicity of 1,1,1,3,3,3-hexamethyldisilazane (CAS 999-97-3, EC 213-668-5)

However, further testing is not considered necessary because:
• The substance does not have a wide-dispersive use and exposure is expected to be low;
• The substance is not classified for mutagenicity; and
• There is no evidence from the repeated dose studies that the substance is able to induce hyperplasia or pre-neoplastic lesions.

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

There are no data to suggest that 1,1,1,3,3,3-hexamethyldisilazane (CAS 999-97-3, EC 213-668-5) should be classified for carcinogenicity.

Additional information