2-phenoxyethanol

Epidemiological data

Administrative data

Endpoint:

epidemiological data

Type of information:

other: Epidemiological study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

Contact sensitization to Euxyl K400

Author:

Bordel-Gómez, M.T. and Miranda-Romero, A.

Year:

2009

Bibliographic source:

Actas Dermosifilográficas 100, 201-4

Materials and methods

Study type:

other: retrospective study

Endpoint addressed:

skin sensitisation

Principles of method if other than guideline:

Retrospective analysis of medical records

GLP compliance:

no

Remarks:

not applicable

Test material

Test material information

Constituent 1

Reference substance name:

2-phenoxyethanol

EC Number:

204-589-7

EC Name:

2-phenoxyethanol

Cas Number:

122-99-6

Molecular formula:

C8H10O2

IUPAC Name:

2-phenoxyethan-1-ol

Specific details on test material used for the study:

- Name of test material (as cited in study report): 2-Phenoxyethanol
- Analytical purity: no data

Method

Type of population:

other: patients attended in a skin allergy unit

Details on study design:

HYPOTHESIS TESTED: Prevalence of sensitisation

METHOD OF DATA COLLECTION
- Type: Record review

STUDY POPULATION
- Total population: 1092
- Selection criteria: Patch test-treated patients
- Sex/age/race: 61,6 % women/41.8 ± 16.1 years/not specified

HEALTH EFFECTS STUDIED
- Disease(s): Prevalence of sensitisation

Exposure assessment:

not specified

Statistical methods:

Statistical analysis was done by means of contingency tables using Pearson's chi-square test for categorical variables and Fisher's Student's t-test for quantitative variables. Agreement between sensitisation to Euxyl K400 and it components was calculated by means of contingency tables using the Kappa ponderate index (Kp).

Results and discussion

Results:

Only 15 patients developed a positive reaction to Euxyl K400 (consisting of MDGN and 2 -Phenoxyethanol in a proportion of 1 to 4). Of these, 11 were positive to MDGN and 2 to phenoxyethanol. Sensitisation was more common in men. The agreement between sensitisation to Euxyl K400 and MDGN was good (Kp = 0.68), whereas agreement between Euxyl K400 and phenoxyethanol was poor (Kp = 0.23).