Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 203-713-7 | CAS number: 109-86-4
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Reference is included as supportive information for animal testing results. Not directly useable for hazard classification purposes
Data source
Reference
- Reference Type:
- publication
- Title:
- Chemical burns of the human cornea
- Author:
- McLaughlin RS
- Year:
- 1 946
- Bibliographic source:
- Am J Opthamology 29, p1355-62.
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- eye irritation
Test guideline
- Qualifier:
- no guideline required
Test material
- Reference substance name:
- 2-methoxyethanol
- EC Number:
- 203-713-7
- EC Name:
- 2-methoxyethanol
- Cas Number:
- 109-86-4
- Molecular formula:
- C3H8O2
- IUPAC Name:
- 2-methoxyethanol
- Test material form:
- liquid
Constituent 1
Method
- Type of population:
- not specified
- Subjects:
- Publication contains extracts from case reports covering a three year period of chemical burns to the eye treated by the author. Single report of case involving methoxyethanol (methyl ‘Cellosolve’) where prompt healing was reported to have occurred within 48 hours following the author’s recommended first aid treatment. First aid treatment was long flushing with water followed by treatment as required by an opthalmologist within 2 hours of exposure and denudation.
- Route of exposure:
- ocular
- Reason of exposure:
- accidental
Results and discussion
- Results of examinations:
- Healing occured within 48 hours,
Applicant's summary and conclusion
- Executive summary:
A case history of human eye exposure to 2 -methoxyethanol showed that prompt healing occured within 48 hours, suggesting that human eye irritancy potential is low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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