Registration Dossier
Registration Dossier
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EC number: 208-909-6 | CAS number: 546-68-9
Endpoint summary
Administrative data
Description of key information
Additional information
Titanium tetraisopropanolate is hydrolytically unstable (half-life < 3 minutes) and the organic degradation product (isopropyl alcohol; IPA) decomposes rapidly. Therefore, the adsorption coefficient is relevant for the main degradation product, and the estimated Koc value of 1.53 L/kg is used in CSA. The Koc value of IPA is estimated by using KOCWIN v.2 (US EPA. 2012, Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.10) .
The other degradation product (hydrated titanium dioxide) of the target substance is not relevant to be further considered in CSA as it is a solid inorganic precipitate released from the substance after hydrolysis (Scholz T. 2010). It is a non-classified substance having low toxicity to human health and the environment. This decomposition product is insoluble in water and therefore lacking bioavailability. According to the report of International Programme on Chemical Safety, titanium is also poorly absorbed and retained by both animals and plants (WHO 1982).
General discussion of transport and distribution is presented in section 4 of CSR.
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