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EC number: 203-603-9
CAS number: 108-65-6
Results are found as attachment:
Table 1: Maternal Measurements in rats
Table 2: Reproductive Parameters in rats
Table 3: Fetal alterations among rats
In this study, Fischer 344 rats were
exposed by inhalation to Propylene Glycol Monomethyl Ether (PGME) during
pregnancy (GD6 -GD15) at doses of 0, 500, 1500 and 3000 ppm.
Maternal toxicity (mild transient CNS
depression, decreased food consumption and body weight gain) were
observed in animals at 3000 ppm. There were no statistically identified
differences in the number of pregnancies, litter size, resorption rate,
fetal body weight and length in any of the groups exposed to PGME when
compared to controls. Slight fetotoxicity (delayed sternebral
ossification) was observed in rats exposed to 3000 ppm. There were no
effects observed among rats exposed to 500 and 1500ppm.
In conclusion, PGME was not considered
teratogenic in rats at exposures up to 3000 ppm, though slight
fetotoxicity was observed in rats exposed to 3000 ppm. Based on the
results, the NOAEL for maternal and fetotoxicity was considered to be
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